ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

Base Information

Chemical Name:ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate
CAS No.:953802-78-3
Molecular Formula:C₂₀H₁₇BrF₂N₂O₃
Molecular Weight:451.267
Hs Code.:

Synonyms:ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

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Chemical Property of ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

Chemical Property:

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Technology Process of ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

There total 4 articles about ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 953802-78-3
ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 36 h / Reflux

2: tetrabutyl-ammonium chloride; trichlorophosphate / 68 h / Reflux

3: acetic acid / ethanol / 24 h / Reflux

With tetrabutyl-ammonium chloride; potassium carbonate; acetic acid; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.3390/PH11040136

Reference yield:

: 846023-33-4
4-bromo-3-ethoxyaniline hydrochloride

: 953802-78-3
ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 36 h / Reflux

2: tetrabutyl-ammonium chloride; trichlorophosphate / 68 h / Reflux

3: acetic acid / ethanol / 24 h / Reflux

With tetrabutyl-ammonium chloride; potassium carbonate; acetic acid; trichlorophosphate; In ethanol; acetonitrile;
DOI:10.3390/PH11040136

Reference yield:

: diethyl 2-(((4-bromo-3-ethoxyphenyl)amino)methylene)malonate

: 953802-78-3
ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride; trichlorophosphate / 68 h / Reflux

2: acetic acid / ethanol / 24 h / Reflux

With tetrabutyl-ammonium chloride; acetic acid; trichlorophosphate; In ethanol;
DOI:10.3390/PH11040136