ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate

Base Information

Chemical Name:ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate
CAS No.:953801-12-2
Molecular Formula:C₂₅H₂₈F₂N₄O₃
Molecular Weight:470.519
Hs Code.:

Synonyms:ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate

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Chemical Property of ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate

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Technology Process of ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate

There total 6 articles about ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 109-01-3
1-methyl-piperazine

: 953802-78-3
ethyl 6-bromo-4-((2,4-difluorophenyl)amino)-7-ethoxyquinoline-3-carboxylate

: 953801-12-2
ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 100 ℃; for 60h; Inert atmosphere;
DOI:10.3390/PH11040136

Reference yield:

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 953801-12-2
ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 36 h / Reflux

2: tetrabutyl-ammonium chloride; trichlorophosphate / 68 h / Reflux

3: acetic acid / ethanol / 24 h / Reflux

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 60 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; trichlorophosphate; In ethanol; toluene; acetonitrile;
DOI:10.3390/PH11040136

Reference yield:

: 846023-33-4
4-bromo-3-ethoxyaniline hydrochloride

: 953801-12-2
ethyl 4-((2,4-difluorophenyl)amino)-7-ethoxy-6-(4-methylpiperazin-1-yl)quinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 36 h / Reflux

2: tetrabutyl-ammonium chloride; trichlorophosphate / 68 h / Reflux

3: acetic acid / ethanol / 24 h / Reflux

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 60 h / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrabutyl-ammonium chloride; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; trichlorophosphate; In ethanol; toluene; acetonitrile;
DOI:10.3390/PH11040136