(S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

Base Information

Chemical Name:(S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate
CAS No.:1378315-05-9
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:

Synonyms:(S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

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Technology Process of (S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

There total 5 articles about (S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 1378315-03-7
(S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

: 1378315-05-9
(S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol300980k

Reference yield:

: 1378315-02-6
(S)-tert-butyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

: 1378315-05-9
(S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With dmap; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ol300980k

Reference yield:

: 103-82-2
phenylacetic acid

: 1378315-05-9
(S)-2,6-dimethylphenyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: pivaloyl chloride; triethylamine / toluene / 14 h / 80 - 110 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - -50 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

4: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

With dmap; sodium hexamethyldisilazane; pivaloyl chloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol300980k