(S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

Base Information

Chemical Name:(S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid
CAS No.:1378315-03-7
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:

Synonyms:(S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

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Chemical Property of (S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

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Technology Process of (S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

There total 4 articles about (S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1378315-02-6
(S)-tert-butyl 4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoate

: 1378315-03-7
(S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol300980k

Reference yield:

: 103-82-2
phenylacetic acid

: 1378315-03-7
(S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pivaloyl chloride; triethylamine / toluene / 14 h / 80 - 110 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - -50 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium hexamethyldisilazane; pivaloyl chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol300980k

Reference yield:

: 17016-83-0
(4S)-4-isopropyl-1,3-oxazolidin-2-one

: 1378315-03-7
(S)-4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)-4-oxo-3-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: pivaloyl chloride; triethylamine / toluene / 14 h / 80 - 110 °C / Inert atmosphere

2: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 - -50 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium hexamethyldisilazane; pivaloyl chloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/ol300980k