(2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol

Base Information

Chemical Name:(2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol
CAS No.:103201-82-7
Molecular Formula:C₁₁H₂₁NO
Molecular Weight:183.294
Hs Code.:
DSSTox Substance ID:DTXSID801231731

Synonyms:(2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol;SCHEMBL7383859;AXYPCLBJVCTKIG-MNOVXSKESA-N;DTXSID801231731;103201-82-7;(2-S-trans)-4-cyclohexyl-2-pyrrolidinemethanol;(2S-trans)-4-cyclohexyl-2-pyrrol idinemethanol;2-Pyrrolidinemethanol, 4-cyclohexyl-, (2S-trans)-

Suppliers and Price of (2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:183.162314293
Heavy Atom Count:13
Complexity:154

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCC(CC1)C2CC(NC2)CO
Isomeric SMILES:C1CCC(CC1)[C@@H]2C[C@H](NC2)CO

Technology Process of (2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol

There total 8 articles about (2S-trans)-4-cyclohexyl-2-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 103201-81-6,103201-87-2
((2S,4S)-1-Benzyl-4-cyclohex-2-enyl-pyrrolidin-2-yl)-methanol

: 103201-82-7
trans-4-cyclohexyl-L-prolinol

Guidance literature:: With hydrogen; 10% palladium on active carbon; In acetic acid; ethyl acetate; for 2h; under 2327.2 Torr;
DOI:10.1021/jo00366a011

Reference yield: 51.0%

: 90657-55-9
trans-4-cyclohexyl-L-proline hydrochloride

: 103201-82-7
trans-4-cyclohexyl-L-prolinol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1021/jo00366a011

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 103201-82-7
trans-4-cyclohexyl-L-prolinol

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / TosOH / toluene / 9 h / Heating

2: 1.) LDA, / 1.) THF, -78 deg C, 30 min, 2.) THF, -20 deg C, 20 min

3: 100 percent / LAH / tetrahydrofuran / 1 h / Heating

4: 65 percent / H₂ / 10percentPd/C / ethyl acetate; acetic acid / 2 h / 2327.2 Torr

With lithium aluminium tetrahydride; hydrogen; toluene-4-sulfonic acid; lithium diisopropyl amide; 10% palladium on active carbon; In tetrahydrofuran; acetic acid; ethyl acetate; toluene;
DOI:10.1021/jo00366a011