3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride

Base Information

Chemical Name:3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride
CAS No.:1355770-58-9
Molecular Formula:C₁₆H₂₁N₃O₃S
Molecular Weight:335.427
Hs Code.:

Synonyms:3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride

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Chemical Property of 3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride

Chemical Property:

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Technology Process of 3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride

There total 5 articles about 3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 4-((5-(3,5-dimethylisoxazol-4-yl)-2-methylphenyl)sulfonyl)piperazine-1-carboxylate

: 1355770-58-9
3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/jm201283q

Reference yield:

: 936074-44-1
5-(3,5-dimethylisoxazol-4-yl)-2-methylbenzene-1-sulfonyl chloride

: 1355770-58-9
3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: bis(isopropyl)ethylamine / dichloromethane / 2.5 h

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With bis(isopropyl)ethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm201283q

Reference yield:

: 10557-85-4
4-iodo-3,5-dimethylisoxazole

: 1355770-58-9
3,5-dimethyl-4-(4-methyl-3-(piperazin-1-ylsulfonyl)phenyl)isoxazole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,2-dimethoxyethane / 2 h / 85 °C

2: chlorosulfonic acid; phosphorus pentachloride / 1,2-dimethoxyethane / 4.25 h / 0 - 70 °C / Inert atmosphere

3: bis(isopropyl)ethylamine / dichloromethane / 2.5 h

4: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(isopropyl)ethylamine; phosphorus pentachloride; sodium hydrogencarbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; 1: Suzuki coupling;
DOI:10.1021/jm201283q