10557-85-4Relevant articles and documents
A new, mild one-pot synthesis of iodinated heterocycles as suitable precursors for N-heterocyclic carbene complexes
Iglesias, Manuel,Schuster, Oliver,Albrecht, Martin
, p. 5423 - 5425 (2010)
The use of I2/AgOAc in dichloromethane constitutes a cheap, mild, and efficient method for the selective iodination of a variety of heterocycles. In a number of cases, this method provides superior yields to other literature methods and affords iodo-functionalized heterocycles that are suitable precursors for carbene complexes.
Structure-based design of orally bioavailable 1 h -Pyrrolo[3,2- C ]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)
Naud, Sébastien,Westwood, Isaac M.,Faisal, Amir,Sheldrake, Peter,Bavetsias, Vassilios,Atrash, Butrus,Cheung, Kwai-Ming J.,Liu, Manjuan,Hayes, Angela,Schmitt, Jessica,Wood, Amy,Choi, Vanessa,Boxall, Kathy,Mak, Grace,Gurden, Mark,Valenti, Melanie,De Haven Brandon, Alexis,Henley, Alan,Baker, Ross,McAndrew, Craig,Matijssen, Berry,Burke, Rosemary,Hoelder, Swen,Eccles, Suzanne A.,Raynaud, Florence I.,Linardopoulos, Spiros,Van Montfort, Rob L. M.,Blagg, Julian
supporting information, p. 10045 - 10065 (2014/01/17)
The protein kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers. MPS1 is one of the top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy. PTEN-defic
IMIDAZO [4, 5-C] QUINOLINE DERIVATES AS BROMODOMAIN INHIBITORS
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Page/Page column 40-41, (2011/06/11)
Novel compounds of Formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.