2-Fluoro-4-(1-hydroxyethyl)benzonitrile

Base Information

Chemical Name:2-Fluoro-4-(1-hydroxyethyl)benzonitrile
CAS No.:440105-59-9
Molecular Formula:C9H8 F N O
Molecular Weight:165.167
Hs Code.:
DSSTox Substance ID:DTXSID901280367
Mol file:440105-59-9.mol

Synonyms:2-fluoro-4-(1-hydroxyethyl)benzonitrile;440105-59-9;1-(4-cyano-3-fluorophenyl)ethanol;SCHEMBL7715291;RPLAOBQEYAQRNN-UHFFFAOYSA-N;DTXSID901280367;AKOS006314911

Suppliers and Price of 2-Fluoro-4-(1-hydroxyethyl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2-FLUORO-4-(1-HYDROXYETHYL)BENZONITRILE 95.00%
5MG
$ 499.31

Total 2 raw suppliers

Chemical Property of 2-Fluoro-4-(1-hydroxyethyl)benzonitrile

Chemical Property:

PSA：44.02000
LogP:1.75068
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:165.058992041
Heavy Atom Count:12
Complexity:198

Purity/Quality:

98% ^*data from raw suppliers

2-FLUORO-4-(1-HYDROXYETHYL)BENZONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=CC(=C(C=C1)C#N)F)O

Technology Process of 2-Fluoro-4-(1-hydroxyethyl)benzonitrile

There total 5 articles about 2-Fluoro-4-(1-hydroxyethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 75-16-1
methylmagnesium bromide

: 101048-76-4
4-cyano-3-fluorobenzaldehyde

: 440105-59-9
2-fluoro-4-(1-hydroxyethyl)benzonitrile

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h;
DOI:10.1021/jm010531d

Reference yield:

: 101048-76-4
4-cyano-3-fluorobenzaldehyde

: 440105-59-9
2-fluoro-4-(1-hydroxyethyl)benzonitrile

Guidance literature:: With MeMgBr; In tetrahydrofuran; diethyl ether;

Reference yield:

: 440105-58-8
α,α-dibromo-4-cyano-3-fluorotoluene

: 440105-59-9
2-fluoro-4-(1-hydroxyethyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / aq. AgNO₃ / ethanol / 3 h / Heating

2: 74 percent / tetrahydrofuran; diethyl ether / 1 h / -78 °C

With silver nitrate; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1021/jm010531d