N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride

Base Information

Chemical Name:N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride
CAS No.:1101119-30-5
Molecular Formula:C₂₀H₂₁N₇O₅S*ClH
Molecular Weight:507.958
Hs Code.:

Synonyms:N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride

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Chemical Property of N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride

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Technology Process of N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride

There total 7 articles about N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 1101118-97-1
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-fluoro-N-methyl-5-nitrobenzenesulfonohydrazide

: 1101119-30-5
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride

Guidance literature:: 2-(N,N-dimethylamino)ethanol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-fluoro-N-methyl-5-nitrobenzenesulfonohydrazide; In tetrahydrofuran; for 1h;

With hydrogenchloride; In methanol; dichloromethane; for 0.5h;
DOI:10.1016/j.bmcl.2016.11.078

Reference yield:

: 1101120-78-8
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide

: 1101119-30-5
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; dichloromethane; for 0.5h;

Reference yield:

: 1101120-03-9
pyrazolo[1,5-a]pyridine-5-carboxamide

: 1101119-30-5
N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-(2-(dimethylamino)ethoxy)-N-methyl-5-nitrobenzenesulfonohydrazide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 18.5 h / 0 - 20 °C

1.2: 1 h / 0 °C / pH 10

2.1: 2,6-dimethylpyridine / methanol / 1 h

2.2: 2 h

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

3.2: 1 h

4.1: hydrogenchloride / methanol; dichloromethane / 0.5 h

With 2,6-dimethylpyridine; hydrogenchloride; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 1.1: Vilsmeier Formylation;