(4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone

Base Information

Chemical Name:(4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone
CAS No.:193966-55-1
Molecular Formula:C₃₇H₄₆N₂O₃S
Molecular Weight:598.85
Hs Code.:

Synonyms:(4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone

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Chemical Property of (4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone

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Technology Process of (4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone

There total 4 articles about (4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 102-81-8
N,N-dibutyl amino-2 ethanol

: 193966-49-3
4-fluorophenyl 2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone

: 193966-55-1
(4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone

Guidance literature:: N,N-dibutyl amino-2 ethanol; With sodium hydride; In N,N-dimethyl-formamide; for 0.25h;

4-fluorophenyl 2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]thiophen-3-yl ketone; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Further stages.;
DOI:10.1021/jm9903388

Reference yield:

: 1081-73-8
1-[2-(4-bromophenoxy)ethyl]pyrrolidine

: 193966-55-1
(4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; 2 N aq. Na₂CO₃ / benzene; ethanol / 3 h / 50 °C

2.1: 90 percent / TiCl₄ / CH₂Cl₂ / 0 - 20 °C

3.1: NaH / dimethylformamide / 0.25 h

3.2: 52 percent / dimethylformamide / 5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; sodium hydride; sodium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: Suzuki coupling / 2.1: Acylation / 3.1: deprotonation / 3.2: Condensation;
DOI:10.1021/jm9903388

Reference yield:

: 98437-23-1
benzo[b]thiophene-2-boronic acid

: 193966-55-1
(4-[2-(di-n-butylamino)ethoxy]phenyl)-(2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]benzo[b]-thiophen-3-yl)ketone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 76 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾; 2 N aq. Na₂CO₃ / benzene; ethanol / 3 h / 50 °C

2.1: 90 percent / TiCl₄ / CH₂Cl₂ / 0 - 20 °C

3.1: NaH / dimethylformamide / 0.25 h

3.2: 52 percent / dimethylformamide / 5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; sodium hydride; sodium carbonate; In ethanol; dichloromethane; N,N-dimethyl-formamide; benzene; 1.1: Suzuki coupling / 2.1: Acylation / 3.1: deprotonation / 3.2: Condensation;
DOI:10.1021/jm9903388