3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate

Base Information

Chemical Name:3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate
CAS No.:89245-74-9
Molecular Formula:C₂₂H₃₂N₂O₃
Molecular Weight:372.508
Hs Code.:

Synonyms:3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate

Chemical Property:

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Technology Process of 3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate

There total 4 articles about 3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 622-93-5
3-diethylamino-propan-1-ol

: 89245-59-0
α-cyclohexyl-1,2-benzisoxazole-3-acetic acid

: 89245-74-9
3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate

Guidance literature:: With triethylamine; p-toluenesulfonyl chloride; In toluene; 1.) 1 h, RT; 2.) 3 h, 70 deg C;
DOI:10.1248/cpb.35.2095

Reference yield:

: 626-62-0
Cyclohexyl iodide

: 89245-74-9
3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 33 percent / 60 percent NaH / dimethylformamide; paraffin / 0.5 h / Ambient temperature

2: 84 percent / NaOH / H₂O; ethanol / 0.5 h / 60 °C

3: 88 percent / p-toluenesulfonyl chloride, triethylamine / toluene / 1.) 1 h, RT; 2.) 3 h, 70 deg C

With sodium hydroxide; sodium hydride; triethylamine; p-toluenesulfonyl chloride; In ethanol; water; N,N-dimethyl-formamide; toluene; paraffin;
DOI:10.1248/cpb.35.2095

Reference yield:

: 89245-60-3
methyl α-cyclohexyl-1,2-benzisoxazole-3-acetate

: 89245-74-9
3-(N,N-diethylamino)-propyl 2-(1,2-benzisoxazol-3-yl)-2-cyclohexylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / NaOH / H₂O; ethanol / 0.5 h / 60 °C

2: 88 percent / p-toluenesulfonyl chloride, triethylamine / toluene / 1.) 1 h, RT; 2.) 3 h, 70 deg C

With sodium hydroxide; triethylamine; p-toluenesulfonyl chloride; In ethanol; water; toluene;
DOI:10.1248/cpb.35.2095