4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol

Base Information

• Chemical Name: 4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol
• CAS No.: 85393-99-3
• Molecular Formula: C₃₁H₄₂O₄
• Molecular Weight: 478.672
• Mol file: 85393-99-3.mol

Synonyms:4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol

Chemical Property of 4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol

There total 5 articles about 4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3'β-benzyloxy-17'β-hydroxy-5'β-androst-15'-en-17'α-yl)furan-2-carbaldehyde ethylene acetal (85393-98-2) → 4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol (85393-99-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 4-dimethylaminopyridine / pyridine / 72 h / Ambient temperature

2: CaCO₃ / acetone; H₂O / 96 h / Heating

3: H₂ / 10percent Pd/CaCO₃ / ethanol / Ambient temperature

4: 1N HCl / tetrahydrofuran / 1 h

5: NaBH₄ / tetrahydrofuran; methanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; calcium carbonate; dmap; Lindlar's catalyst; In tetrahydrofuran; pyridine; methanol; ethanol; water; acetone;

DOI:10.1002/hlca.19820650712

Reference yield:

4-(3'β-benzyloxy-15'β-hydroxy-5'β-androst-16'-en-17'-yl)furan-2-carbaldehyde ethylene acetal (84700-10-7) → 4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol (85393-99-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/CaCO₃ / ethanol / Ambient temperature

2: 1N HCl / tetrahydrofuran / 1 h

3: NaBH₄ / tetrahydrofuran; methanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol;

DOI:10.1002/hlca.19820650712

Reference yield:

Acetic acid (3S,5R,8R,9S,10S,13S,14S,17S)-3-benzyloxy-17-(5-[1,3]dioxolan-2-yl-furan-3-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester → 4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-methanol (85393-99-3)

Guidance literature:

Multi-step reaction with 4 steps

1: CaCO₃ / acetone; H₂O / 96 h / Heating

2: H₂ / 10percent Pd/CaCO₃ / ethanol / Ambient temperature

3: 1N HCl / tetrahydrofuran / 1 h

4: NaBH₄ / tetrahydrofuran; methanol / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; hydrogen; calcium carbonate; Lindlar's catalyst; In tetrahydrofuran; methanol; ethanol; water; acetone;

DOI:10.1002/hlca.19820650712

upstream raw materials:

4-(3'β-benzyloxy-15'β-hydroxy-5'β-androstan-17'β-yl)furan-2-carbaldehyde ethylene acetal

4-(3'β-benzyloxy-17'β-hydroxy-5'β-androst-15'-en-17'α-yl)furan-2-carbaldehyde ethylene acetal

4-(3'β-benzyloxy-15'β-hydroxy-5'β-androst-16'-en-17'-yl)furan-2-carbaldehyde ethylene acetal

Downstream raw materials:

3-(3'β-benzyloxy-5'β-androst-14'-en-17'β-yl)-2H-pyran-2-one