(3R,5R)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

Base Information

Chemical Name:(3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine
CAS No.:119719-68-5
Molecular Formula:C₂₀H₂₄N₂O₄
Molecular Weight:356.422
Hs Code.:

Synonyms:(3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

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Technology Process of (3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

There total 7 articles about (3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 119680-68-1,119680-69-2,119719-74-3,119719-75-4
methyl N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>isoxazolidine-3-carboxylate

: 119719-68-5
(3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

: 119719-69-6
(3S*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 0.5h; Ambient temperature;
DOI:10.1021/jo00270a037

Reference yield:

: 5041-33-8
N-(Benzyloxycarbonyl)allylamine

: 119719-68-5
(3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / molecular sieves (4A) / toluene / 14 h / Heating

2: 93 percent / 10percent HCl / methanol / 4 h / 40 °C

3: 86 percent / K₂CO₃ / dimethylformamide / 1 h / 50 °C

4: 46 percent / LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; 4 A molecular sieve; potassium carbonate; In methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00270a037

Reference yield:

: 100-39-0
benzyl bromide

: 119719-68-5
(3R*,5R*)-N-benzyl-5-<<(benzyloxycarbonyl)amino>methyl>-3-(hydroxymethyl)isoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃ / dimethylformamide / 1 h / 50 °C

2: 46 percent / LiAlH₄ / diethyl ether / 0.5 h / Ambient temperature

With lithium aluminium tetrahydride; potassium carbonate; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jo00270a037