(E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide

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Chemical Name:(E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide
CAS No.:1246350-08-2
Molecular Formula:C₂₅H₃₁N₅O₂
Molecular Weight:433.553
Hs Code.:

Synonyms:(E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide

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Chemical Property of (E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide

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Technology Process of (E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide

There total 6 articles about (E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2680-03-7,68761-83-1
N,N-Dimethylacrylamide

: 1246349-98-3
cyclohexyl-[3-iodo-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-4-yl]-amine

: 1246350-08-2
(E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide

Guidance literature:: With tetra-(n-butyl)ammonium iodide; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; N,N-dimethyl-formamide; at 65 ℃;

Reference yield:

: 871836-51-0
4-chloro-1H-pyrazolo [4,3-c]pyridine

: 1246350-08-2
(E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

2: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

3: butan-1-ol / 20 - 190 °C / Microwave irradiation

4: tetra-(n-butyl)ammonium iodide; triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 65 °C

With iodine; tetra-(n-butyl)ammonium iodide; triethylamine; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1246350-08-2
(E)-3-[4-cyclohexylamino-1-(4-methoxy-benzyl)-1H-pyrazolo[4,3-c]pyridin-3-yl]-N,N-dimethyl-acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2.5 h / -78 °C

1.2: 1.5 h / -78 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

3.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

4.1: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

5.1: butan-1-ol / 20 - 190 °C / Microwave irradiation

6.1: tetra-(n-butyl)ammonium iodide; triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 65 °C

With n-butyllithium; iodine; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; triethylamine; diisopropylamine; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; hexane; water; N,N-dimethyl-formamide; butan-1-ol;