N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

Base Information

Chemical Name:N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide
CAS No.:107962-04-9
Molecular Formula:C₂₂H₂₆BrN₅O
Molecular Weight:456.385
Hs Code.:

Synonyms:N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

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Chemical Property of N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

There total 5 articles about N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 107962-03-8
N-<4-(1H-imidazol-1-yl)butyl>-6-<(4-isopropylphenyl)-amino>-3-pyridinecarboxamide

: 107962-04-9
N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

Guidance literature:: With bromine; In acetic acid; at 15 ℃; for 1h;
DOI:10.1021/jo00388a023

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 107962-04-9
N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 1 h / 60 °C

2: 89.9 percent / 2-methoxy-ethanol / 10 h / Heating

3: 73 percent / bromine / acetic acid / 1 h / 15 °C

With bromine; In 2-methoxy-ethanol; acetic acid; acetonitrile;
DOI:10.1021/jo00388a023

Reference yield:

: 5326-23-8
6-Chloro-3-pyridinecarboxylic acid

: 107962-04-9
N-<4-(1H-imidazol-1-yl)butyl>-6-<<2-bromo-4-(1-methylethyl)phenyl>amino>-3-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 3.5 h / Heating

2: acetonitrile / 1 h / 60 °C

3: 89.9 percent / 2-methoxy-ethanol / 10 h / Heating

4: 73 percent / bromine / acetic acid / 1 h / 15 °C

With thionyl chloride; bromine; In 2-methoxy-ethanol; acetic acid; acetonitrile;
DOI:10.1021/jo00388a023