(2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate

Base Information

Chemical Name:(2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate
CAS No.:1371609-08-3
Molecular Formula:C₁₃H₁₅ClN₂O₃
Molecular Weight:282.727
Hs Code.:

Synonyms:(2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate

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Chemical Property of (2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate

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Technology Process of (2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate

There total 1 articles about (2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 684-93-5
1-methyl-1-nitrosourea

: 1182366-72-8
(2R,3R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid

: 1371609-08-3
(2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate

Guidance literature:: 1-methyl-1-nitrosourea; With potassium hydroxide; In diethyl ether;

(2R,3R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h;

Reference yield:

: 1371609-08-3
(2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate

: 1371609-10-7
2-chloro-4-((4S,5R)-4-(hydroxymethyl)-5-methyl-2-oxooxazolidin-3-yl)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C

2: ethanol; sodium tetrahydroborate / 2 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1371609-08-3
(2R,3R)-methyl 2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoate

: 1371609-11-8
C₁₃H₁₁ClN₂O₃

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C

2: ethanol; sodium tetrahydroborate / 2 h / 0 - 20 °C

3: Dess-Martin periodane / acetonitrile / 0.5 h / 0 - 20 °C

With sodium tetrahydroborate; ethanol; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;