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N-Nitroso-N-methylurea

Base Information Edit
  • Chemical Name:N-Nitroso-N-methylurea
  • CAS No.:684-93-5
  • Deprecated CAS:126742-50-5,820-60-0,820-60-0
  • Molecular Formula:C2H5N3O2
  • Molecular Weight:103.081
  • Hs Code.:29241990
  • European Community (EC) Number:211-678-4
  • NSC Number:23909
  • UN Number:2811,3077
  • UNII:W8KW4E3XSU
  • DSSTox Substance ID:DTXSID4021006
  • Nikkaji Number:J3.020A
  • Wikipedia:N-Nitroso-N-methylurea
  • Wikidata:Q3023727
  • NCI Thesaurus Code:C645
  • Metabolomics Workbench ID:52534
  • ChEMBL ID:CHEMBL288958
  • Mol file:684-93-5.mol
N-Nitroso-N-methylurea

Synonyms:Methylnitrosourea;N Methyl N nitrosourea;N-Methyl-N-nitrosourea;Nitrosomethylurea;NSC 23909;NSC-23909;NSC23909

Suppliers and Price of N-Nitroso-N-methylurea
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • N-Methyl-N-nitrosoUrea(ContainsWater)
  • 25g
  • $ 640.00
  • TRC
  • N-Methyl-N-nitrosoUrea(ContainsWater)
  • 5g
  • $ 305.00
  • Oakwood
  • N-Nitroso-N-methylurea wet with 10% acetic acid solution
  • 1g
  • $ 40.00
  • Oakwood
  • N-Nitroso-N-methylurea wet with 10% acetic acid solution
  • 5g
  • $ 94.00
  • Oakwood
  • N-Nitroso-N-methylurea wet with 10% acetic acid solution
  • 25g
  • $ 180.00
  • Oakwood
  • N-Nitroso-N-methylurea wet with 10% acetic acid solution
  • 250mg
  • $ 24.00
  • Oakwood
  • N-Nitroso-N-methylurea wet with 10% acetic acid solution
  • 100g
  • $ 460.00
  • Medical Isotopes, Inc.
  • N-Methyl-N-nitrosoUrea(ContainsWater)
  • 1 g
  • $ 610.00
  • Medical Isotopes, Inc.
  • N-Nitroso-N-methylurea
  • 5 g
  • $ 290.00
  • Medical Isotopes, Inc.
  • N-Nitroso-N-methylurea
  • 1 g
  • $ 190.00
Total 114 raw suppliers
Chemical Property of N-Nitroso-N-methylurea Edit
Chemical Property:
  • Appearance/Colour:Off-white to pale yellow solid 
  • Vapor Pressure:0.605mmHg at 25°C 
  • Melting Point:119-124°C 
  • Refractive Index:1.574 
  • Boiling Point:164.3 °C at 760 mmHg 
  • PKA:12.36±0.50(Predicted) 
  • Flash Point:53.1 °C 
  • PSA:75.76000 
  • Density:1.46 g/cm3 
  • LogP:0.37860 
  • Storage Temp.:2-8°C 
  • Water Solubility.:Soluble. <0.1 g/100 mL at 18 C 
  • XLogP3:0
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:0
  • Exact Mass:103.038176411
  • Heavy Atom Count:7
  • Complexity:90.9
  • Transport DOT Label:Poison
Purity/Quality:

99% *data from raw suppliers

N-Methyl-N-nitrosoUrea(ContainsWater) *data from reagent suppliers

Safty Information:
  • Pictogram(s): FlammableF; Toxic
  • Hazard Codes:F,T 
  • Statements: 45-46-61-11-25 
  • Safety Statements: 53-45-24/25-22 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Nitrogen Compounds -> Nitrosamines
  • Canonical SMILES:CN(C(=O)N)N=O
  • Description Methylnitrosourea (MNU) is a methylated nitrosourea compound with alkylating,mutagenic, teratogenic, carcinogenic, and cytotoxic properties. The toxic effects of MNU are caused by the transfer of its methyl group to nucleobases in nucleic acids.
  • Uses Precursor of Diazomethane. It has a cytotoxicity effect. This product contains an undetermined amount of water MNU is the starting material for diazomethane generation. Diazomethane provides methyl derivatives with carboxylic acids and phenols in a very smooth and gentle reaction. Phenols are slower in their reactivity compared to carboxylic acids and should be converted at temperatures greater than 0 C. However, since MNU is unstable at temperatures greater than 20 C and is shock sensitive to a degree, other (N-methyl) nitrosamides have replaced MNU for use in diazomethane generation, and most chemical supply houses no longer carry MNU. MNU has been studied as a chemotherapeutic agent as it is an effective therapy for mice that are intraperitoneally or intracerebrally implanted with L1210 leukemia cells. MNU is currently used as a research chemical to develop animal models for human diseases.
Technology Process of N-Nitroso-N-methylurea

There total 11 articles about N-Nitroso-N-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With dinitrogen tetroxide impregnated on activated charcoal; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1081/SCC-200057999
Guidance literature:
urea; methylamine; With hydrogenchloride; In water; for 3h; Reflux;
With sodium nitrite; at 0 - 20 ℃;
DOI:10.1002/ejoc.201701610
Guidance literature:
With sulfuric acid; water; at 0 ℃;
DOI:10.1021/jm201150j
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