4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid

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Chemical Name:4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid
CAS No.:1432914-09-4
Molecular Formula:C₃₂H₂₄ClFN₄O₇S
Molecular Weight:663.083
Hs Code.:

Synonyms:4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid

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Chemical Property of 4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid

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Technology Process of 4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid

There total 3 articles about 4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432914-06-1
N-(2,4-dimethoxybenzyl)-3,4-difluoro-N-(pyrimidin-2-yl)benzenesulfonamide

: 1432914-08-3
5-(5-chloro-2-hydroxyphenyl)benzo[d]oxazol-2(3H)-one

: 1432914-09-4
4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 70 - 80 ℃; for 16h;

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1432914-09-4
4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 16 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C

2.2: 1 h / -78 - 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 16 h / 70 - 80 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1275699-51-8
N-(2,4-dimethoxybenzyl)pyrimidin-2-amine

: 1432914-09-4
4-(4-chloro-2-(2-oxo-2,3-dihydrobenzo[]oxazol-5-yl)phenoxy)N-(2,4-dimethoxybenzyl)-3-fluoro-N-(pyrimidin-2-yl)benzenesulfonamid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 - 20 °C

1.2: 1 h / -78 - 20 °C

2.1: potassium carbonate / dimethyl sulfoxide / 16 h / 70 - 80 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide;