methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate

Base Information

• Chemical Name: methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate
• CAS No.: 353254-39-4
• Molecular Formula: C₁₆H₁₅N₃O₄
• Molecular Weight: 313.313
• Mol file: 353254-39-4.mol

Synonyms:methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate

Chemical Property of methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate

There total 3 articles about methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-cyanoacetate (105-56-6) + methyl 2-(p-methoxyphenylhydrazone)-3-oxopentanoate → methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate (353254-39-4)

Guidance literature:

With ammonium acetate; acetic acid; In benzene; for 6h; Heating;

DOI:10.1016/0040-4020(95)00829-W

Reference yield:

methyl propanoyl acetate (30414-53-0) → methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate (353254-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / sodium acetate / ethanol / Ambient temperature

2: 90 percent / ammonium acetate, acetic acid / benzene / 6 h / Heating

With ammonium acetate; sodium acetate; acetic acid; In ethanol; benzene;

DOI:10.1016/0040-4020(95)00829-W

Reference yield:

para-methoxyphenyldiazonium chloride (4346-59-2) → methyl 5-cyano-1,6-dihydro-4-ethyl-1-(p-methoxyphenyl)-6-oxopyridazine-3-carboxylate (353254-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / sodium acetate / ethanol / Ambient temperature

2: 90 percent / ammonium acetate, acetic acid / benzene / 6 h / Heating

With ammonium acetate; sodium acetate; acetic acid; In ethanol; benzene;

DOI:10.1016/0040-4020(95)00829-W

upstream raw materials:

ethyl 2-cyanoacetate

methyl propanoyl acetate

para-methoxyphenyldiazonium chloride

Downstream raw materials:

methyl 5-amino-3,4-dihydro-7-methyl-3-(p-methoxyphenyl)-4-oxothieno<3,4-d>pyridazine-1-carboxylate