4346-59-2Relevant academic research and scientific papers
Visible-light fluorescence photomodulation in azo-BF2 switches
Qian, Hai,Shao, Baihao,Aprahamian, Ivan
, p. 4901 - 4904 (2017)
Azo-BF2 switches 1 and 2 with their extended phenanthridinyl π-system exhibit red-light fluorescence whose intensity can be photomodulated using visible-light. The para-methoxy group in 2 leads to a bathochromic shift in the emission band, push
Process development of 5-methoxy-1H-indole-2-carboxylic acid from ethyl 2-methylmalonate
Bessard, Yves
, p. 214 - 220 (1998)
Development is described of a new process for the preparation from malonates of 5-methoxy-1H-indole-2-carboxylic acid esters, useful intermediates in the synthesis of pharmaceutical compounds. The process uses readily available starting materials, produces little waste, can be operated safely on at least 1 molar scale, and gives high yields. The main areas of optimization included the azo coupling of a diazonium salt with malonate derivatives, the Japp-Klingemann rearrangement, and the Fischer indole synthesis.
A comprehensive spectroscopic, solvatochromic and photochemical analysis of 5-hydroxyquinoline and 8-hydroxyquinoline mono-azo dyes
Coelho, Paulo J.,Lup, Andrew Ng Kay,Mahon, Peter J.,Pesyan, Nader Noroozi,Ramezanitaghartapeh, Mohammad,Raposo, M. Manuela M.,Rashidnejad, Hamid,Soltani, Alireza
, (2020/10/06)
A series of novel substituted-azo dyes 8-(aryldiazenyl)quinolin-5-ol (5a-i) were synthesized by the coupling reaction of 5-hydroxyquinoline with diazotized aniline derivatives in the presence of NaNO2 in HCl/H2O mixture. The study of
Synthesis and characterization for new Zn(II) complexes and their optimizing fertilization performance in planting corn hybrid
Althagafi, Ismail,Morad, Moataz,Al-dawood, Aisha Y.,Yarkandy, Naema,Katouah, Hanadi A.,Hossan, Aisha S.,Khedr, Abdalla M.,El-Metwaly, Nashwa M.,Ibraheem, Farag
, p. 2121 - 2133 (2021/01/07)
Novel Zn(II)–benzohydrazide complexes have been synthesized using Zn(NO3)2·6H2O salt. All new synthesises were investigated by available analytical and spectral tools to demonstrate their formulae. Binuclear complexes were
Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122
Cong, Xiaonan,Ding, Tao,He, Yundong,Liu, Mingyao,Liu, Yongrui,Peng, Shihong,Shao, Ting,Wang, Dingxiang,Wu, Haigang,Yi, Zhengfang,Zheng, Jianghua
, (2021/06/25)
Prostate cancer (PCa) is a common aggressive disease worldwide which usually progresses into incurable castration-resistant prostate cancer (CRPC) in most cases after 18–24 months treatment. Androgen receptor (AR) has been considered as a crucial factor involved in CRPC and the study of AR as a potential therapeutic target in CRPC may be helpful in disease control and life-cycle management. In this study, we identified a potent small molecule compound, HG122, that suppressed CRPC cells proliferation and metastasis, and inhibited tumor growth both in subcutaneous and orthotopic tumor model. In addition, HG122 reduced the mRNA expression of PSA and TMPRSS2 which are target genes of AR, resulting in cell growth inhibition and metastasis suppression of CRPC, without affecting the expression of AR mRNA level. Mechanically, HG122 promoted AR protein degradation through the proteasome pathway impairing the AR signaling pathway. In conclusion, HG122 overcomes enzalutamide (ENZ) resistance in CRPC both in vitro and in vivo, thus suggesting HG122 is a potential candidate for the clinical prevention and treatment of CRPC.
Synthesis and antioxidant assay of new nicotinonitrile analogues clubbed thiazole, pyrazole and/or pyridine ring systems
Abumelha, Hana M. A.
, (2020/01/21)
A series of novel nicotinonitrile derivatives were synthesized by hybridization with thiazole, pyrazole, and pyridine ring systems using 4-aminobenzohydrazide as link-bridge. The synthetic strategy of nicotinonitrile-thiazole analogues involves cyclizatio
Uses of ethyl benzoyl acetate for the synthesis of thiophene, pyran, and pyridine derivatives with antitumor activities
Ibrahim, Bishoy A.,Mohareb, Rafat M.
, p. 4023 - 4035 (2020/09/21)
The N-(arly)propanamide derivatives 3a,b were used for a series of heterocyclization reactions to give thiophene, pyran, and pyridine derivatives. Thus, these compounds underwent the Gewald's thiophene synthesis through their reactions with either malononitrile or ethyl cyanoacetate and elemental sulfur to afford compounds 6a-f, respectively. In addition, they were subjected through a series of multicomponent reactions (MCRs) to give pyran and fused derivatives. The reactions of 3a,b with either malononitrile or ethyl cyanoacetate gave pyridine derivatives 14a-d, respectively. The latter compounds afforded arylhydrazone derivatives 15a-m through their reactions with any of the aromatic diazonium salts 15a-c. The antitumor of the synthesized compounds against A549 (nonsmall cell lung cancer), H460 (human lung cancer), HT-29 (human colon cancer), and MKN-45 (human gastric cancer cancer) cancer cell lines together with foretinib as the positive control by a MTT assay was measured, and the results obtained showed that many compounds exhibited high potency against the six cancer cell lines.
3-Aminopyrazolo[4,3-c]pyridine-4,6-dione as a precursor for novel pyrazolo[4,5,1-ij][1,6]naphthyridines and pyrido[4’,3’:3,4]pyrazolo[1,5-a]pyrimidines
Metwally, Nadia H.,Deeb, Emad A.
supporting information, p. 1614 - 1628 (2018/06/14)
The versatile, 3-aminopyrazolo[4,3-c]pyridine-4,6-dione (2) was synthesized and allowed to react with aldehydes, aryldiazonium chlorides, chalcones and enaminones to afford regioselectively the novel pyrazolo[4,3-c]pyridine derivatives 4a-c, pyrazolo[4,5,
(E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides as tubulin polymerization inhibitors: Structure-based bioisosterism design, synthesis, biological evaluation, molecular docking and in silico ADME prediction
Wang, Guangcheng,Peng, Zhiyun,Peng, Shanshan,Qiu, Jie,Li, Yongjun,Lan, Yanyu
supporting information, p. 3350 - 3355 (2018/09/12)
A series of (E)-N-Aryl-2-oxo-2-(3,4,5-trimethoxyphenyl)acetohydrazonoyl cyanides have been synthesized and evaluated for their anticancer activity in human hepatocellular liver carcinoma HepG2 and breast adenocarcinoma MCF-7 cell lines. Among all the test
Frozen aryldiazonium chlorides in radical reactions with alkenes and arenes
Thon, Daniel,Fürst, Michael C.D.,Altmann, Lisa-Marie,Heinrich, Markus R.
, p. 5289 - 5294 (2018/07/06)
Frozen aryldiazonium chlorides have been investigated in radical alkene and arene functionalizations. Through freezing at – 84 °C, aryldiazonium chlorides, which otherwise show significant decomposition in aqueous solution after several hours at room temp
