2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

Base Information

• Chemical Name: 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide
• CAS No.: 1290088-93-5
• Molecular Formula: C₃₄H₃₂FN₃O₂
• Molecular Weight: 533.645
• Mol file: 1290088-93-5.mol

Synonyms:2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

Chemical Property of 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide

There total 5 articles about 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C28H27IN2O2 (1332647-15-0) + 4-fluoroaniline (371-40-4) → 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide (1290088-93-5)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; for 7h; stereoselective reaction; Reflux;

DOI:10.1016/j.tet.2011.02.005

Reference yield:

2-iodophenylamine (615-43-0) → 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide (1290088-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 0.5 h / 20 °C

1.2: 0.25 h / 20 °C

1.3: 24 h / 20 °C

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 7 h / Reflux

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene; 1.1: Ugi condensation / 1.2: Ugi condensation / 1.3: Ugi condensation / 2.1: domino Heck-Buchwald reaction;

DOI:10.1016/j.tet.2011.02.005

Reference yield:

Benzyl isocyanide (88333-03-3,10340-91-7) → 2-((Z)-3-((4-fluorophenylamino)(phenyl)methylene)-2-oxoindolin-1-yl)-N-benzyl-4-methylpentanamide (1290088-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 0.5 h / 20 °C

1.2: 0.25 h / 20 °C

1.3: 24 h / 20 °C

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 7 h / Reflux

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene; 1.1: Ugi condensation / 1.2: Ugi condensation / 1.3: Ugi condensation / 2.1: domino Heck-Buchwald reaction;

DOI:10.1016/j.tet.2011.02.005

upstream raw materials:

C₂₈H₂₇IN₂O₂

4-fluoroaniline

Benzyl isocyanide

2-iodophenylamine