1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

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Chemical Name:1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine
CAS No.:1315484-41-3
Molecular Formula:C₁₈H₁₇N₅
Molecular Weight:303.366
Hs Code.:

Synonyms:1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

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Chemical Property of 1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

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Technology Process of 1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

There total 8 articles about 1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1315483-84-1
1-(azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

: 65-85-0,8013-63-6
benzoic acid

: 1315484-41-3
1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In methanol; 1,2-dichloro-ethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm300438j

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1315484-41-3
1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 23.5 h / -5 - 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.2 h / 120 °C / Microwave irradiation

4: 10% Pd(OH)₂ on C; hydrogen / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

5: toluene-4-sulfonic acid / toluene / 2 h / 110 °C

6: sodium hydroxide / tetrahydrofuran; methanol; water / 90 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8: sodium tris(acetoxy)borohydride; acetic acid / methanol; 1,2-dichloro-ethane / 18 h / 20 °C / Inert atmosphere

With dmap; 10% Pd(OH)₂ on C; hydrogen; tetrabutylammonium nitrate; sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol; toluene;
DOI:10.1021/jm300438j

Reference yield:

: 1315494-65-5
3-[[5-amino-1-(phenylsulfony)l-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]-azetidine-1-carboxylic acid tert-butyl ester

: 1315484-41-3
1-(1-phenylmethyl-azetidin-3-yl)-1,6-dihydro-imidazo[4,5-d]pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 2 h / 110 °C

2: sodium hydroxide / tetrahydrofuran; methanol; water / 90 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / methanol; 1,2-dichloro-ethane / 18 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm300438j