3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester
CAS No.:1315494-66-6
Molecular Formula:C₂₂H₂₃N₅O₄S
Molecular Weight:453.522
Hs Code.:

Synonyms:3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester

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Technology Process of 3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1315494-66-6
3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 23.5 h / -5 - 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.2 h / 120 °C / Microwave irradiation

4: 10% Pd(OH)₂ on C; hydrogen / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

5: toluene-4-sulfonic acid / toluene / 2 h / 110 °C

With dmap; 10% Pd(OH)₂ on C; hydrogen; tetrabutylammonium nitrate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1021/jm300438j

Reference yield:

: 1315494-65-5
3-[[5-amino-1-(phenylsulfony)l-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]-azetidine-1-carboxylic acid tert-butyl ester

: 122-51-0
orthoformic acid triethyl ester

: 1315494-66-6
3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 110 ℃; for 2h;
DOI:10.1021/jm300438j

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1315494-66-6
3-[6-(phenylsulfonyl)-imidazo[4,5-d]pyrrolo[2,3-b]pyridine-1(6H)-yl]-azetidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; triethylamine / dichloromethane / 20 °C

2: tetrabutylammonium nitrate; trifluoroacetic anhydride / dichloromethane / 23.5 h / -5 - 20 °C

3: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.2 h / 120 °C / Microwave irradiation

4: 10% Pd(OH)₂ on C; hydrogen / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

5: toluene-4-sulfonic acid / toluene / 2 h / 110 °C

With dmap; 10% Pd(OH)₂ on C; hydrogen; tetrabutylammonium nitrate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; isopropyl alcohol; toluene;
DOI:10.1021/jm300438j