Ethyl 1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate
CAS No.:167888-36-0
Molecular Formula:C₁₆H₁₄F₂N₂O₅
Molecular Weight:352.294
Hs Code.:2933499090
DSSTox Substance ID:DTXSID70444194
Nikkaji Number:J1.976.896A
Wikidata:Q82262252
Mol file:167888-36-0.mol

Synonyms:167888-36-0;ETHYL 1-CYCLOPROPYL-6,7-DIFLUORO-8-METHYL-5-NITRO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE;ethyl 1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxoquinoline-3-carboxylate;ETHYL 1-CYCLOPROPY1-6,7-DIFLUORO-8-METHYL-5-NITRO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE;SCHEMBL7520230;DTXSID70444194;A810915;1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-3-quinolinecarboxylic acid ethyl ester;Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methyl-5-nitro-4-oxoquinoline-3-carboxylate;Ethyl1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate;1-Cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester;ethyl 1-cyclopropyl-6,7-bis(fluoranyl)-8-methyl-5-nitro-4-oxidanylidene-quinoline-3-carboxylate

Suppliers and Price of Ethyl 1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of Ethyl 1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.609
Boiling Point:519.4°Cat760mmHg
Flash Point:267.9°C
PSA：104.98000
Density:1.514g/cm³
LogP:2.72280
XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:352.08707788
Heavy Atom Count:25
Complexity:631

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN(C2=C(C(=C(C(=C2C1=O)[N+](=O)[O-])F)F)C)C3CC3

Technology Process of Ethyl 1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate

There total 10 articles about Ethyl 1-cyclopropyl-6,7-difluoro-8-methyl-5-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (Z)-3-Cyclopropylamino-2-(2,4,5-trifluoro-3-methyl-6-nitro-benzoyl)-acrylic acid ethyl ester

: 167888-36-0
Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methyl-5-nitro-4-oxoquinoline-3-carboxylate

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; at 70 ℃; for 8h;
DOI:10.1248/cpb.44.1074

Reference yield: 77.6%

: ethyl 2-(2,4,5-trifluoro-3-methyl-6-nitrobenzoyl)-3-dimethylaminoacrylate

: 765-30-0
Cyclopropylamine

: 167888-36-0
Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methyl-5-nitro-4-oxoquinoline-3-carboxylate

Guidance literature:: With hydrogenchloride; potassium carbonate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

Reference yield: 77.6%

: ethyl 2-(2,4,5-trifluoro-3-methyl-6-nitrobenzoyl)-3-dimethylaminoacrylate

: 765-30-0
Cyclopropylamine

: 167888-36-0
Ethyl 1-cyclopropyl-6,7-difluoro-1,4-dihydro-8-methyl-5-nitro-4-oxoquinoline-3-carboxylate

Guidance literature:: ethyl 2-(2,4,5-trifluoro-3-methyl-6-nitrobenzoyl)-3-dimethylaminoacrylate; Cyclopropylamine; In tetrahydrofuran; at 20 ℃; for 4h;

With potassium carbonate; N,N-dimethyl-formamide; at 20 - 60 ℃; for 17h;

With hydrogenchloride; In water; at 20 ℃; for 3h; pH=3;