Imidazo[1,2-a]pyridin-5-ylmethanol

Base Information

• Chemical Name: Imidazo[1,2-a]pyridin-5-ylmethanol
• CAS No.: 167884-17-5
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID10456074
• Mol file: 167884-17-5.mol

Synonyms:Imidazo[1,2-a]pyridin-5-ylmethanol;167884-17-5;Imidazo[1,2-a]pyridine-5-methanol;SCHEMBL7846380;DTXSID10456074;HTTSIZUFZZFCTK-UHFFFAOYSA-N;MFCD13183181;5-hydroxymethylimidazo[1,2-a]pyridine;AKOS016006425;Imidazo[1,2-a]pyridin-5-yl-methanol;{imidazo[1,2-a]pyridin-5-yl}methanol;AS-50301;CS-0084723;FT-0718856;EN300-112798;O11828;A882208;F8881-3040;Z1255495400

Chemical Property of Imidazo[1,2-a]pyridin-5-ylmethanol

Chemical Property:

• PKA: 13.09±0.10(Predicted)
• PSA: 37.53000
• Density: 1.26±0.1 g/cm3(Predicted)
• LogP: 0.82660
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

97% ^*data from raw suppliers

imidazo[1,2-a]pyridin-5-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=CN2C(=C1)CO

Technology Process of Imidazo[1,2-a]pyridin-5-ylmethanol

There total 4 articles about Imidazo[1,2-a]pyridin-5-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloroethanal (107-20-0) + (6-Amino-pyridin-2-yl)-methanol (79651-64-2) → 5-hydroxymethylimidazo[1,2-a]pyridine (167884-17-5)

Guidance literature:

In ethanol; water; at 100 ℃; for 2h; Sealed tube; Inert atmosphere;

DOI:10.1002/chem.201705370

Reference yield: 86.0%

ethyl (imidazo[1,2-a]pyridin-5-yl)carboxylate (177485-39-1) → 5-hydroxymethylimidazo[1,2-a]pyridine (167884-17-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 3h;

DOI:10.1021/jo015582x

Reference yield: 48.7%

imidazo[1,2-a]pyridine-5-carboxylic acid (479028-72-3) → 5-hydroxymethylimidazo[1,2-a]pyridine (167884-17-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;

upstream raw materials:

ethyl (imidazo[1,2-a]pyridin-5-yl)carboxylate

ethyl 6-aminopicolinate

2-chloroethanal

(6-Amino-pyridin-2-yl)-methanol

Downstream raw materials:

imidazo[1,2-a]pyridine-5-carbaldehyde

(Z)-ethyl α-[(triphenylphosphoranylidene)amino]-β-(imidazo[1,2-a]pyridin-5-yl)propenoate