1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine

Base Information

Chemical Name:1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine
CAS No.:110417-68-0
Molecular Formula:C₁₃H₁₈N₂O₃S
Molecular Weight:282.364
Hs Code.:

Synonyms:1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine

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Chemical Property of 1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine

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Technology Process of 1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine

There total 6 articles about 1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 110417-53-3
cis-1-methyl-4-<(2-phenylethenyl)sulfonyl>piperazine

: 110417-68-0
1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine

Guidance literature:: With potassium hydroxide; potassium hypochlorite; tetra(n-butyl)ammonium hydrogensulfate; In diethyl ether; at 20 ℃; for 14h;
DOI:10.1021/jm00395a010

Reference yield:

: 109-01-3
1-methyl-piperazine

: 110417-68-0
1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 3 h / Ambient temperature

2: 54 percent / t-BuOK / dioxane; 2-methyl-propan-2-ol / 3 h / Ambient temperature

3: 27 percent / aq. NaPO₂H₂ / 5percent Pd/BaSO₄ / ethanol / 15 h / Heating

4: 48 percent / KOCl, conc. KOH, tetrabutylammonium hydrogen sulfate / diethyl ether / 14 h / 20 °C

With potassium hydroxide; sodium hypophosphite; potassium hypochlorite; potassium tert-butylate; tetra(n-butyl)ammonium hydrogensulfate; Pd-BaSO₄; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm00395a010

Reference yield:

: 52147-97-4
trans 2-phenylethenesulfonyl chloride

: 110417-68-0
1-Methyl-4-((2S,3R)-3-phenyl-oxiranesulfonyl)-piperazine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Br₂, 2.) NEt₃ / 1.) CCl₄, RT, 2.) Et₂O, -5 deg C

2: CH₂Cl₂ / 3 h / Ambient temperature

3: 54 percent / t-BuOK / dioxane; 2-methyl-propan-2-ol / 3 h / Ambient temperature

4: 27 percent / aq. NaPO₂H₂ / 5percent Pd/BaSO₄ / ethanol / 15 h / Heating

5: 48 percent / KOCl, conc. KOH, tetrabutylammonium hydrogen sulfate / diethyl ether / 14 h / 20 °C

With potassium hydroxide; sodium hypophosphite; potassium hypochlorite; potassium tert-butylate; bromine; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; Pd-BaSO₄; In 1,4-dioxane; diethyl ether; ethanol; dichloromethane; tert-butyl alcohol;
DOI:10.1021/jm00395a010