52147-97-4

Basic information

• Product Name: BETA-STYRENE SULFONYL CHLORIDE
• Synonyms: BETA-VINYLBENZENESULFONYL CHLORIDE;BETA-STYRENE SULFONYL CHLORIDE;TRANS-BETA-STYRENESULFONYL CHLORIDE;trans-β-styrenesulfonyl chloride;TRNS- -STYRENESULFONYHL CHLORIDE;({E})-2-phenylethylenesulfonyl chloride;(E)-2-phenylethene-1-sulfonyl chloride;β-STYRENE SULFONYL CHLORIDE
• CAS NO: 52147-97-4
• Molecular Formula: C₈H₇ClO₂S
• Molecular Weight: 202.66
• Product Categories: Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 52147-97-4.mol
• Article Data: 20

Chemical Properties

• Melting Point: 85-88 °C(lit.)
• Boiling Point: 322.3±25.0 °C(Predicted)
• Appearance: /
• Density: 1.385±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: BETA-STYRENE SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BETA-STYRENE SULFONYL CHLORIDE(52147-97-4)
• EPA Substance Registry System: BETA-STYRENE SULFONYL CHLORIDE(52147-97-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 52147-97-4(Hazardous Substances Data)

Usage

General Description

Beta-styrene sulfonyl chloride, also known as beta-sulfoethylbenzene chloride, is a chemical compound with the formula C8H7ClO2S. It is a clear, colorless to pale yellow liquid that is primarily used in the production of pharmaceuticals and agrochemicals as a key intermediate. Beta-styrene sulfonyl chloride is also utilized in the synthesis of specialty chemicals, dyes, and organic compounds. It is known for its high reactivity and ability to undergo various chemical transformations, making it a versatile building block in organic synthesis. However, it is important to handle beta-styrene sulfonyl chloride with caution as it can be harmful if ingested, inhaled, or comes into contact with the skin or eyes.

Upstream product

• 14554-08-6 ethyl (E)-2-phenylethenesulfonate 
• 98-85-1 1-Phenylethanol 
• 100-42-5 styrene 

Downstream Products

• 73300-78-4 2-Phenylvinylsulfonsaeure-methylester 
• 16212-06-9 phenyl styryl sulfone 
• 1674-29-9 (1,2,2-trichloro-ethyl)-benzene 
• 15436-11-0 (E)-methyl styryl sulfone 
• 16212-08-1 1-methyl-4-[(E)-2-phenylethenesulfonyl]benzene 
• 64984-09-4 (E)-(2-phenylethenyl)sulfonamide 
• 13719-47-6 (E)-N,2-diphenylethene-1-sulfonamide 
• 4363-40-0 2t-phenyl-ethenesulfinic acid 
• 405-18-5 trans-2-phenylethene-1-sulfonyl fluoride 
• 52148-01-3 2-nitro-trans-styrene-sulfonyl chloride-(β) 
• 52148-00-2 trans-2-(p-nitrophenyl)ethenesulfonyl chloride 
• 17299-32-0 (E)-4-<(2-phenylethynyl)sulfonyl>morpholine 
• 110417-47-5 1-Methyl-4-((E)-2-phenyl-ethenesulfonyl)-piperazine 
• 886-65-7 trans,trans-1,4-Diphenyl-1,3-butadiene 

Relevant articles and documents

Highly efficient azido-Ugi multicomponent reactions for the synthesis of bioactive tetrazoles bearing sulfonamide scaffolds

Recent studies revealed that the contribution of the different bioactive scaffolds in one structure creates modern drugs/compounds with unique synergistic biological properties. In this regard, thanks to the interesting biological and medicinal properties

Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator

The main pathway responsible for cellular regulation against oxidative stress is nuclear factor E2-related factor-2 (Nrf2) signaling. We previously synthesized and reported a novel vinyl sulfone (1) as an Nrf2 activator with therapeutic potential for Parkinson's disease (PD). In this study, we changed the vinyl sulfone to vinyl sulfonamide or vinyl sulfonate to improve Nrf2 activating efficacy. We observed that the introduction of vinyl sulfonamide led to a reduction of the effects on Nrf2 activation, whereas vinyl sulfonate compounds exhibited superior activity compared to the vinyl sulfone compounds. Among the vinyl sulfonates, 3c exhibited 6.9- and 83.5-fold higher effects on Nrf2 activation than the corresponding vinyl sulfone (1) and vinyl sulfonamide (2c), respectively. Compound 3c was confirmed to induce expression of the Nrf2-dependent antioxidant enzymes at the protein level in cells. In addition, 3c mitigated PD-associated behavioral deficits by protecting DAergic neurons in the MPTP-induced mouse model of PD.

Green approach for the synthesis of thiophenyl pyrazoles and isoxazoles by adopting 1,3-dipolar cycloaddition methodology and their antimicrobial activity

A variety of N-((1,3-diphenyl-5-aryl-1H-pyrazol-4-yl)sulfonyl)thiophene-2-carboxamides (7) and N-((5-aryl-3-phenylisoxazol-4-yl)sulfonyl)thiophene-2-carboxamides (8) were prepared from (E)-N-(arylethenesulfonyl)thiophene-2-carboxamides (4) adopting 1,3-di