5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester

Base Information

Chemical Name:5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester
CAS No.:613242-42-5
Molecular Formula:C₂₉H₃₂N₄O₈
Molecular Weight:564.595
Hs Code.:

5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-<i>tert</i>-butyl ester

Synonyms:5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester

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Chemical Property of 5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester

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Technology Process of 5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester

There total 12 articles about 5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 100-39-0
benzyl bromide

: 613242-41-4
5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 3'''-tert-butyl ester

: 613242-42-5
5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 1038925-90-4
2-((1S,2R)-1-benzyloxycarbonylamino-2-hydroxypropyl)oxazole-4-carboxylic acid methyl ester

: 613242-42-5
5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / 10 percent Pd-C / methanol

2.1: 90 percent / benzyltriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆(-); (i-Pr)2NEt / dimethylformamide

3.1: 88 percent / Et₃N / CHCl₃

4.1: NBS / CHCl₃

4.2: 85 percent / Et₃N / CHCl₃

5.1: 83 percent / Cs₂CO₃ / dioxane / 60 °C

6.1: 100 percent / LiOH / methanol

7.1: 84 percent / Et₃N / dimethylformamide

With lithium hydroxide; N-Bromosuccinimide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 613242-59-4
(4'S,5'R)-2',2',5'-Trimethyl-4',5'-dihydro-[2,4']bioxazolyl-4,3'-dicarboxylic acid 3'-benzyl ester 4-methyl ester

: 613242-42-5
5',5'',2''',2'''-tetramethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: TFA / CHCl₃

2.1: H₂ / 10 percent Pd-C / methanol

3.1: 90 percent / benzyltriazol-1-yloxy-tris(dimethylamino)phosphonium PF₆(-); (i-Pr)2NEt / dimethylformamide

4.1: 88 percent / Et₃N / CHCl₃

5.1: NBS / CHCl₃

5.2: 85 percent / Et₃N / CHCl₃

6.1: 83 percent / Cs₂CO₃ / dioxane / 60 °C

7.1: 100 percent / LiOH / methanol

8.1: 84 percent / Et₃N / dimethylformamide

With lithium hydroxide; N-Bromosuccinimide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide;