4-(4-Methoxyphenyl)piperazine-1-carboximidamide

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)piperazine-1-carboximidamide
• CAS No.: 77723-17-2
• Molecular Formula: C₁₂H₁₈N₄O
• Molecular Weight: 234.301
• DSSTox Substance ID: DTXSID701243666

Synonyms:4-(4-methoxyphenyl)piperazine-1-carboximidamide;77723-17-2;4-(4-methoxyphenyl)-1-piperazinecarboximidamide;SCHEMBL8931665;FIFLVAAKXGHCLX-UHFFFAOYSA-N;DTXSID701243666;STL196544;AKOS000225160;BS-4422

Chemical Property of 4-(4-Methoxyphenyl)piperazine-1-carboximidamide

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 234.14806121
• Heavy Atom Count: 17
• Complexity: 255

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N2CCN(CC2)C(=N)N

Technology Process of 4-(4-Methoxyphenyl)piperazine-1-carboximidamide

There total 1 articles about 4-(4-Methoxyphenyl)piperazine-1-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(4-methoxyphenyl)piperazine (38212-30-5) + S-Methylisothiourea sulfate (867-44-7,147895-43-0) → 4-(4-methoxyphenyl)piperazine-1-carboximidamide (77723-17-2)

Guidance literature:

4-(4-methoxyphenyl)piperazine; S-Methylisothiourea sulfate; In water; for 2h; Reflux;

With barium(II) chloride; In water; for 1.5h; Reflux;

DOI:10.1007/s11426-011-4477-6

Reference yield: 45.0%

4-(4-methoxyphenyl)piperazine-1-carboximidamide (77723-17-2) + 6,7-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-one (1097802-78-2) + benzaldehyde (100-52-7) → 8,9-difluoro-2-(4-(4-methoxyphenyl)piperazin-1-yl)-4-phenyl-4,5-dihydro-1H-thiochromeno[4,3-d]pyrimidine

Guidance literature:

With potassium hydroxide; In water; acetonitrile; for 0.0833333h; Microwave irradiation;

DOI:10.1007/s11426-011-4477-6

Reference yield:

N-[3-(dimethylamino)methylene]amino]-2-propenylidene]-N-methylmethanaminium perchlorate + 4-(4-methoxyphenyl)piperazine-1-carboximidamide (77723-17-2) → N-[(dimethylamino)methylene]-2-[4-(4-methoxyphenyl)-1-piperazinyl]-5-pyrimidinamine

Guidance literature:

With sodium methylate; In methanol; propan-1-ol;

upstream raw materials:

4-(4-methoxyphenyl)piperazine

S-Methylisothiourea sulfate

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