N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide
CAS No.:863772-08-1
Molecular Formula:C₁₄H₁₄F₃N₅O₂
Molecular Weight:341.293
Hs Code.:

Synonyms:N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

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Chemical Property of N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

There total 3 articles about N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 383-63-1
ethyl trifluoroacetate,

: 1292802-00-6
6-(4-(aminomethyl)benzyloxy)pyrimidine-2,4-diamine

: 863772-08-1
N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃; for 2h;
DOI:10.1021/ja200225m

Reference yield:

: 39895-56-2
4-hydroxymethyl-benzylamine

: 863772-08-1
N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; sodium / para-xylene / 120 °C

1.2: 3 h / 150 °C

2.1: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 20 °C

With pyridine; sodium; N-ethyl-N,N-diisopropylamine; In ethanol; para-xylene;
DOI:10.1021/ja200225m

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 863772-08-1
N-(4-((2,6-diaminopyrimidin-4-yloxy)methyl)benzyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran

2.1: pyridine; sodium / para-xylene / 120 °C

2.2: 3 h / 150 °C

3.1: N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 20 °C

With pyridine; lithium aluminium tetrahydride; sodium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; para-xylene;
DOI:10.1021/ja200225m