(3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide

Base Information

Chemical Name:(3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide
CAS No.:634905-03-6
Molecular Formula:Br*C₃₀H₃₁N₂O₃
Molecular Weight:547.492
Hs Code.:

Synonyms:(3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide

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Chemical Property of (3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide

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Technology Process of (3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide

There total 7 articles about (3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: ABBF hydrochloride

: 100-39-0
benzyl bromide

: 634905-03-6
(3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: ABBF hydrochloride; benzyl bromide; With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 50 ℃; for 20h;

With hydrogen bromide; In water;

Reference yield:

: 95-56-7
2-hydroxybromobenzene

: 634905-03-6
(3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; magnesium chloride / acetonitrile / 4 h / Heating / reflux

2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / 6 h / 130 °C

2.2: 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 90 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 20 h / 20 - 55 °C

5.1: hydrogenchloride / methanol; water

6.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 h / 50 °C

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; magnesium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; DMF (N,N-dimethyl-formamide); water; acetonitrile;

Reference yield:

: 550998-59-9
7-bromobenzofuran-2-carboxylic acid

: 634905-03-6
(3R)-1-benzyl-3-({[7-(2-methoxyphenyl)-1-benzofuran-2-yl]carbonyl}amino)-1-azoniabicyclo[2.2.2]octane bromide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 18 h / 90 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 20 h / 20 - 55 °C

3.1: hydrogenchloride / methanol; H₂₀

3.2: 2 h / 55 °C

4.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 h / 50 °C

With hydrogenchloride; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; DMF (N,N-dimethyl-formamide); H₂₀; water;