(E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate
CAS No.:1415412-19-9
Molecular Formula:C₁₈H₁₇NO₅
Molecular Weight:327.337
Hs Code.:

Synonyms:(E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

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Chemical Property of (E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

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Technology Process of (E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

There total 3 articles about (E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1071-46-1
hydrogen ethyl malonate

: 696-62-8
para-iodoanisole

: 552-89-6
2-nitro-benzaldehyde

: 1415412-19-9
(E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

Guidance literature:: hydrogen ethyl malonate; para-iodoanisole; 2-nitro-benzaldehyde; With ammonium formate; In N,N-dimethyl-formamide; at 135 ℃; for 2h;

With potassium carbonate; In N,N-dimethyl-formamide; at 135 ℃; for 18h;
DOI:10.1039/c5ra00228a

Reference yield:

: 696-62-8
para-iodoanisole

: 24393-59-7
(E)-ethyl 3-(2-nitrophenyl)acrylate

: 1264276-65-4
ethyl (Z)-3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

: 1415412-19-9
(E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 6h; Overall yield = 72 %; Overall yield = 105 mg; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.10.062

Reference yield:

: 609-73-4
o-nitroiodobenzene

: 140-88-5,9003-32-1
ethyl acrylate

: 1264276-65-4
ethyl (Z)-3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

: 1415412-19-9
(E)-ethyl 3-(4-methoxyphenyl)-3-(2-nitrophenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 110 °C / Inert atmosphere

With potassium carbonate; In N,N-dimethyl-formamide; 1: |Heck Reaction / 2: |Heck Reaction;
DOI:10.1016/j.tetlet.2012.10.062