3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N2-cyclopentylmethyl-N2-ethylpyridine-2,5-diamine

Base Information

Chemical Name:3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine
CAS No.:957216-31-8
Molecular Formula:C₂₅H₃₀F₆N₈
Molecular Weight:556.557
Hs Code.:

Synonyms:3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine

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Chemical Property of 3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine

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Technology Process of 3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine

There total 7 articles about 3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: (3-{[(3,5-bistrifluoromethyl-benzyl)(2-methyl-2H-tetrazol-5-yI)amino]methyl}-5-nitro-pyridin-2-yl)cyclopentylmethyIethylamine

: 957216-31-8
3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine

Guidance literature:: With hydrogen; Pd/C ethylenediamine complex; In methanol; ethyl acetate; at 20 ℃; for 8h;

Reference yield:

: 957216-46-5
(3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}pyridin-2-yl)cyclopentylmethylethylamine

: 957216-31-8
3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / 1.5 h / 0 - 20 °C

2: hydrogen / Pd/C ethylenediamine complex / methanol; ethyl acetate / 8 h / 20 °C

With sulfuric acid; hydrogen; nitric acid; Pd/C ethylenediamine complex; In methanol; ethyl acetate;

Reference yield:

: 957216-45-4
2-(cyclopentylmethylethylamino)pyridine-3-carbaldehyde

: 957216-31-8
3-{[(3,5-bistrifluoromethylbenzyl)(2-methyl-2H-tetrazol-5-yl)amino]methyl}-N*2*-cyclopentylmethyl-N*2*-ethylpyridine-2,5-diamine

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 1 h / 20 °C

3: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / -5 °C

4: sulfuric acid; nitric acid / 1.5 h / 0 - 20 °C

5: hydrogen / Pd/C ethylenediamine complex / methanol; ethyl acetate / 8 h / 20 °C

With sodium tetrahydroborate; sulfuric acid; potassium tert-butylate; hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; Pd/C ethylenediamine complex; In methanol; ethyl acetate; N,N-dimethyl-formamide; toluene;