2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester

Base Information

• Chemical Name: 2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester
• CAS No.: 905954-22-5
• Molecular Formula: C₂₈H₃₁O₅P
• Molecular Weight: 478.525
• Mol file: 905954-22-5.mol

Synonyms:2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester

Chemical Property of 2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester

There total 1 articles about 2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenyl(p-tolyl)phosphine oxide (6840-28-4) + ethyl diethyl malonate (133-13-1) → (p-dibromomethylphenyl)diphenylphosphine oxide + 2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester (905954-22-5)

Guidance literature:

diphenyl(p-tolyl)phosphine oxide; With N-Bromosuccinimide; In tetrachloromethane; for 8h; Heating;

ethyl diethyl malonate; With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 8h;

DOI:10.1021/ol0608045

Reference yield: 83.0%

2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester (905954-22-5) → 2-(4-diphenylphosphanyl-benzyl)-2-ethyl-malonic acid diethyl ester

Guidance literature:

With trichlorosilane; phenylsilane; at 60 ℃; for 6h;

DOI:10.1021/ol0608045

Reference yield:

2-[4-(diphenyl-phosphinoyl)-benzyl]-2-ethyl-malonic acid diethyl ester (905954-22-5) → 5-[4-(Ph2P)benzyl]-5-ethyl-2,4,6-(1H,3H,5H)-pyrimidinetrione

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / phenylsilane; trichlorosilane / 6 h / 60 °C

2: 81 percent / NaH / dimethylformamide / 24 h / 100 °C

With trichlorosilane; phenylsilane; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/ol0608045

upstream raw materials:

diphenyl(p-tolyl)phosphine oxide

ethyl diethyl malonate