{2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester

Base Information

Chemical Name:{2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester
CAS No.:53266-65-2
Molecular Formula:C₂₀H₁₄Cl₂N₄O₆
Molecular Weight:477.26
Hs Code.:

Synonyms:{2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester

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Chemical Property of {2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester

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Technology Process of {2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester

There total 7 articles about {2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53334-38-6
(2-{[3-Chloro-4-(4-chloro-benzoyl)-phenyl]-hydrazono}-3-ethoxycarbonylamino-3-oxo-propionyl)-carbamic acid ethyl ester

: 53266-65-2
{2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester

Guidance literature:: With sodium acetate; In water; acetic acid; at 106 ℃; for 2h;
DOI:10.1021/jm00355a019

Reference yield:

: 50274-64-1
(2-chloro-4-nitrophenyl)(4-chlorophenyl)-methanone

: 53266-65-2
{2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr

2: 1.) conc. HCl, NaNO₂, 2.) NaOAc / 1.) HOAc, H₂O, 10 deg C, 30 min, 2.) HOAc, H₂O, RT, 1 h

3: NaOAc / acetic acid; H₂O / 2 h / 106 °C

With hydrogenchloride; hydrogen; sodium acetate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; water; acetic acid;
DOI:10.1021/jm00355a019

Reference yield:

: 7073-36-1
2-chloro-4-nitrobenzoyl chloride

: 53266-65-2
{2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carbonyl}-carbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83.5 percent / AlCl₃ / CHCl₃ / a) RT, overnight, b) reflux, 1 h

2: 70 percent / H₂ / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr

3: 1.) conc. HCl, NaNO₂, 2.) NaOAc / 1.) HOAc, H₂O, 10 deg C, 30 min, 2.) HOAc, H₂O, RT, 1 h

4: NaOAc / acetic acid; H₂O / 2 h / 106 °C

With hydrogenchloride; aluminium trichloride; hydrogen; sodium acetate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; chloroform; water; acetic acid;
DOI:10.1021/jm00355a019