Technology Process of 2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid
There total 7 articles about 2-[3-chloro-4-(4-chloro-benzoyl)-phenyl]-3,5-dioxo-2,3,4,5-tetrahydro-[1,2,4]triazine-6-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent / H2 / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr
2: 1.) conc. HCl, NaNO2, 2.) NaOAc / 1.) HOAc, H2O, 10 deg C, 30 min, 2.) HOAc, H2O, RT, 1 h
3: NaOAc / acetic acid; H2O / 2 h / 106 °C
4: 50percent H2SO4 / acetic acid; H2O / 2 h / Heating
With
hydrogenchloride; sulfuric acid; hydrogen; sodium acetate; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; water; acetic acid;
DOI:10.1021/jm00355a019
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83.5 percent / AlCl3 / CHCl3 / a) RT, overnight, b) reflux, 1 h
2: 70 percent / H2 / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr
3: 1.) conc. HCl, NaNO2, 2.) NaOAc / 1.) HOAc, H2O, 10 deg C, 30 min, 2.) HOAc, H2O, RT, 1 h
4: NaOAc / acetic acid; H2O / 2 h / 106 °C
5: 50percent H2SO4 / acetic acid; H2O / 2 h / Heating
With
hydrogenchloride; aluminium trichloride; sulfuric acid; hydrogen; sodium acetate; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; chloroform; water; acetic acid;
DOI:10.1021/jm00355a019
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83.5 percent / AlCl3 / CHCl3 / a) RT, overnight, b) reflux, 1 h
2: 70 percent / H2 / 5percent Pd/C / tetrahydrofuran / 25 °C / 2068.6 - 5171.5 Torr
3: 1.) conc. HCl, NaNO2, 2.) NaOAc / 1.) HOAc, H2O, 10 deg C, 30 min, 2.) HOAc, H2O, RT, 1 h
4: NaOAc / acetic acid; H2O / 2 h / 106 °C
5: 50percent H2SO4 / acetic acid; H2O / 2 h / Heating
With
hydrogenchloride; aluminium trichloride; sulfuric acid; hydrogen; sodium acetate; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; chloroform; water; acetic acid;
DOI:10.1021/jm00355a019
