(S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate

Base Information

Chemical Name:(S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate
CAS No.:1283145-73-2
Molecular Formula:C₂₀H₂₀ClF₃N₂O₃
Molecular Weight:428.839
Hs Code.:

Synonyms:(S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate

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Chemical Property of (S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate

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Technology Process of (S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate

There total 2 articles about (S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.5%

: 1283145-69-6
(S)-ethyl 2-(1-(4-hydroxyphenyl)pyrrolidin-2-yl)acetate

: 69045-84-7
2,3-dichloro-5-trifluoromethylpyridine

: 1283145-73-2
(S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 1283145-68-5
(S)-ethyl 2-(1-(4-(benzyloxy)phenyl)pyrrolidin-2-yl)acetate

: 1283145-73-2
(S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol; ethanol

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With hydrogen; caesium carbonate; palladium 10% on activated carbon; In methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1283145-73-2
(S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate

: 1283142-14-2
(S)-2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetic acid

Guidance literature:: (S)-ethyl 2-(1-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)pyrrolidin-2-yl)acetate; With water; sodium hydroxide; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=~ 2 - ~ 3;