(S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid

Base Information

Chemical Name:(S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid
CAS No.:75651-92-2
Molecular Formula:C₂₈H₃₅N₃O₆
Molecular Weight:509.602
Hs Code.:

Synonyms:(S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid

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Chemical Property of (S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid

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Technology Process of (S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid

There total 4 articles about (S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1427166-46-8
(S)-benzyl 2-(((S)-1-(1H-benzo[d][1,2,3]triazol-1-yl)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

: 75651-92-2
(S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid

Guidance literature:: With triethylamine; In water; acetonitrile; at -40 ℃; for 12h;
DOI:10.1039/c3cc39291k

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 75651-92-2
(S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 0.25 h / 25 °C

1.2: 25 °C

2.1: triethylamine / acetonitrile; water / 12 h / 25 °C

3.1: thionyl chloride / dichloromethane / 0.25 h / 25 °C

3.2: 4 h / 0 °C

4.1: triethylamine / acetonitrile; water / 12 h / -40 °C

With thionyl chloride; triethylamine; In dichloromethane; water; acetonitrile;
DOI:10.1039/c3cc39291k

Reference yield:

: 886981-23-3
benzyl (2S)-2-(1H-1,2,3-benzotriazol-1-ylcarbonyl)tetrahydro-1H-pyrrole-1-carboxylate

: 75651-92-2
(S)-2-((S)-2-((S)-1-((benzyloxy)carbonyl)pyrrolidine-2-carboxamido)-4-methylpentanamido)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile; water / 12 h / 25 °C

2.1: thionyl chloride / dichloromethane / 0.25 h / 25 °C

2.2: 4 h / 0 °C

3.1: triethylamine / acetonitrile; water / 12 h / -40 °C

With thionyl chloride; triethylamine; In dichloromethane; water; acetonitrile;
DOI:10.1039/c3cc39291k