tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate

Base Information

• Chemical Name: tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate
• CAS No.: 166655-24-9
• Molecular Formula: C₂₆H₃₃NO₃Si
• Molecular Weight: 435.638
• Mol file: 166655-24-9.mol

Synonyms:tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate

Chemical Property of tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate

There total 3 articles about tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{[1-(4-chlorophenyl)methylidene]amino}acetic acid tert-butyl ester (166655-36-3) → tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate (166655-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: LDA, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone / tetrahydrofuran; hexane / -78 °C

2: 1 N aq. HCl / diethyl ether

3: diethyl ether

With hydrogenchloride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/jo00104a035

Reference yield:

(3-Bromo-prop-1-ynyl)-tert-butyl-diphenyl-silane → tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate (166655-24-9)

Guidance literature:

Multi-step reaction with 3 steps

1: LDA, 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone / tetrahydrofuran; hexane / -78 °C

2: 1 N aq. HCl / diethyl ether

3: diethyl ether

With hydrogenchloride; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/jo00104a035

Reference yield:

5-(tert-Butyl-diphenyl-silanyl)-2-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-pent-4-ynoic acid tert-butyl ester → tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate (166655-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 N aq. HCl / diethyl ether

2: diethyl ether

With hydrogenchloride; In diethyl ether;

DOI:10.1021/jo00104a035

upstream raw materials:

{[1-(4-chlorophenyl)methylidene]amino}acetic acid tert-butyl ester

Downstream raw materials:

tert-Butyl 2-isocyano-5-(tert-butyldiphenylsilyl)pent-4-ynoate