Glycine, N-[(4-chlorophenyl)methylene]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Glycine, N-[(4-chlorophenyl)methylene]-, 1,1-dimethylethyl ester
• CAS No.: 166655-36-3
• Molecular Formula: C13H16ClNO2
• Molecular Weight: 253.729
• Mol file: 166655-36-3.mol

Synonyms:

Chemical Property of Glycine, N-[(4-chlorophenyl)methylene]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(4-chlorophenyl)methylene]-, 1,1-dimethylethyl ester

There total 1 articles about Glycine, N-[(4-chlorophenyl)methylene]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chlorobenzaldehyde (104-88-1) + glycine tert-butyl ester hydrochloride (27532-96-3) → {[1-(4-chlorophenyl)methylidene]amino}acetic acid tert-butyl ester (166655-36-3)

Guidance literature:

With sodium sulfate; triethylamine; In dichloromethane; at 0 - 20 ℃; for 15h;

DOI:10.1016/j.tet.2015.04.078

Reference yield: 98.0%

allyl bromide (106-95-6) + {[1-(4-chlorophenyl)methylidene]amino}acetic acid tert-butyl ester (166655-36-3) → 2-{[1-(4-chlorophenyl)methylidene]amino}pent-4-enoic acid tert-butyl ester (1173893-39-4)

Guidance literature:

{[1-(4-chlorophenyl)methylidene]amino}acetic acid tert-butyl ester; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

allyl bromide; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1016/j.tetlet.2009.04.099

Reference yield: 98.0%

dimethyl 2-furfurylidenemalonate (74299-84-6) + {[1-(4-chlorophenyl)methylidene]amino}acetic acid tert-butyl ester (166655-36-3) → 2-tert-butyl 4,4-dimethyl (2R,3R,5R)-5-(4-chlorophenyl)-3-(furan-2-yl)pyrrolidine-2,4,4-tricarboxylate (1310576-71-6)

Guidance literature:

With C₂₅H₂₁BrN₂O; copper(II) acetate monohydrate; potassium carbonate; In dichloromethane; at 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.201007960

upstream raw materials:

4-chlorobenzaldehyde

glycine tert-butyl ester hydrochloride

Downstream raw materials:

2',1':1,2;1'',2'':3,4-dinaphthcyclohepta-1,3-diene-6-benzoylamino-6-carboxylic acid tert-butyl ester

tert-Butyl 2-formamido-5-(tert-butyldiphenylsilyl)pent-4-ynoate

tert-Butyl 2-isocyano-5-(tert-butyldiphenylsilyl)pent-4-ynoate