Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

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Chemical Name:Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate
CAS No.:388612-80-4
Molecular Formula:C₃₂H₃₆FN₃O₅Si
Molecular Weight:589.739
Hs Code.:

Synonyms:Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

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Chemical Property of Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

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Technology Process of Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

There total 6 articles about Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 388612-77-9
2-fluoro-3-[3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl]benzoic acid

: 6436-90-4
ethyl 2-(benzylamino)acetate

: 388612-80-4
Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

Guidance literature:: With 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine; In chloroform; at 20 ℃; for 1h;

Reference yield:

: 388612-69-9
3-(2-fluoro-3-iodophenyl)-1-[(2-(trimethylsilyl)-ethoxymethyl)]quinoxalin-2(1H)-one

: 388612-80-4
Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

2: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

3: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 1 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; water; sodium hydrogencarbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 388612-66-6
Ethyl (2-fluoro-3-iodophenyl)oxoacetate

: 388612-80-4
Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 15 h / 120 °C

2: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

3: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

4: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

5: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 1 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; water; sodium hydride; sodium hydrogencarbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;