Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate

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Chemical Name:Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate
CAS No.:388612-81-5
Molecular Formula:C₃₂H₃₅N₃O₅Si
Molecular Weight:569.732
Hs Code.:

Synonyms:Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate

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Chemical Property of Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate

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Technology Process of Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate

There total 7 articles about Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 388612-80-4
Ethyl N-benzyl-N-[2-fluoro-3-(3-oxo-4-(2-(trimethylsilyl)ethoxymethyl)-3,4-dihydroquinoxalin-2-yl)-benzoyl]-aminoacetate

: 388612-81-5
Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

Reference yield:

: 388612-69-9
3-(2-fluoro-3-iodophenyl)-1-[(2-(trimethylsilyl)-ethoxymethyl)]quinoxalin-2(1H)-one

: 388612-81-5
Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

2: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

3: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 1 h / 20 °C

4: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; water; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 388612-66-6
Ethyl (2-fluoro-3-iodophenyl)oxoacetate

: 388612-81-5
Ethyl 2-benzyl-3-oxo-7-(3-oxo-4-[2-(trimethylsilyl)ethoxymethyl]-3,4-dihydroquinoxalin-2-yl)isoindoline-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 15 h / 120 °C

2: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C

3: sodium hydrogencarbonate / 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 70 °C

4: methanol; sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

5: 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine / chloroform / 1 h / 20 °C

6: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 20 °C

With methanol; sodium hydroxide; 2-chloro-1,3-dimethyl imidazolium chloride; water; sodium hydride; sodium hydrogencarbonate; triethylamine; lithium hexamethyldisilazane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In tetrahydrofuran; ethanol; chloroform; N,N-dimethyl-formamide;