(3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol

Base Information

Chemical Name:(3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol
CAS No.:138152-70-2
Molecular Formula:C₂₃H₄₀O₄Si
Molecular Weight:408.654
Hs Code.:

Synonyms:(3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol

Suppliers and Price of (3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol

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Technology Process of (3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol

There total 6 articles about (3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 138152-68-8
(E)-(3R,6R)-1-(Benzyloxy)-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-hepten-3-ol

: 138152-70-2
(3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol

Guidance literature:: With disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃;
DOI:10.1021/jo00027a022

Reference yield:

: 138152-67-7,138152-79-1
(E)-(5R)-7-(Benzyloxy)-2-ethyl-4-methyl-3-heptene-1,5-diol

: 138152-70-2
(R)-3-Benzyloxy-1-{(2R,3R)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-propyl]-2-methyl-oxiranyl}-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NEt₃, DMAP / CH₂Cl₂ / Ambient temperature

2: D-(-)-diethyl tartrate, titanium isopropoxide, tert-butyl hydroperoxide

With titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; diethyl (2S,3S)-tartrate; triethylamine; In dichloromethane;
DOI:10.1021/jo00027a022

Reference yield:

: 138152-67-7,138152-79-1
(E)-(5R)-7-(Benzyloxy)-2-ethyl-4-methyl-3-heptene-1,5-diol

: 138152-70-2
(3R,4S,5S,6R)-1-(Benzyloxy)-4,5-epoxy-6-ethyl-4-methyl-7-<(tert-butyldimethylsilyl)oxy>-4-heptanol

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NEt₃, DMAP / CH₂Cl₂ / Ambient temperature

2: 93 percent / m-CPBA, Na₂HPO₄ / CH₂Cl₂ / 0 °C

With dmap; disodium hydrogenphosphate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jo00027a022