{3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester

Base Information

• Chemical Name: {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester
• CAS No.: 194608-87-2
• Molecular Formula: C₂₄H₂₈ClNO₄S
• Molecular Weight: 462.01

Synonyms:{3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester

Chemical Property of {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester

There total 10 articles about {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',4'-dihydroxypropiophenone (5792-36-9) → {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester (194608-87-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Cs₂CO₃ / dimethylformamide / 20 °C

2.1: 1,2-dichloro-benzene / Heating

3.1: 100 percent / H₂ / 5 percent Pd/C / various solvent(s) / 760 Torr

4.1: Cs₂CO₃ / dimethylformamide

5.1: NH₂OH*HCl; NaOAc / methanol / 4 h / Heating

6.1: Ac₂O / 0.5 h / 20 °C

6.2: pyridine / 3 h / Heating

With hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; caesium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene; 2.1: Claisen rearrangement;

DOI:10.1016/S0960-894X(03)00115-X

Reference yield:

2,4-dihydroxy-3-allylpropiophenone (74815-88-6) → {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester (194608-87-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 100 percent / H₂ / 5 percent Pd/C / various solvent(s) / 760 Torr

2.1: Cs₂CO₃ / dimethylformamide

3.1: NH₂OH*HCl; NaOAc / methanol / 4 h / Heating

4.1: Ac₂O / 0.5 h / 20 °C

4.2: pyridine / 3 h / Heating

With hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; caesium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00115-X

Reference yield:

1-(2-allyloxy-4-hydroxy-phenyl)-propan-1-one → {3-chloro-4-[3-(3-ethyl-7-propyl-benzo[d]isoxazol-6-yloxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester (194608-87-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,2-dichloro-benzene / Heating

2.1: 100 percent / H₂ / 5 percent Pd/C / various solvent(s) / 760 Torr

3.1: Cs₂CO₃ / dimethylformamide

4.1: NH₂OH*HCl; NaOAc / methanol / 4 h / Heating

5.1: Ac₂O / 0.5 h / 20 °C

5.2: pyridine / 3 h / Heating

With hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; caesium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1,2-dichloro-benzene; 1.1: Claisen rearrangement;

DOI:10.1016/S0960-894X(03)00115-X

upstream raw materials:

{3-Chloro-4-[3-(3-hydroxy-4-{1-[(E)-hydroxyimino]-propyl}-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester

2',4'-dihydroxypropiophenone

methyl 3-chloro-4-hydroxyphenylacetate

2,4-dihydroxy-3-propylphenyl ethyl ketone

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