{3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester

Base Information

Chemical Name:{3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester
CAS No.:363622-69-9
Molecular Formula:C₂₉H₃₃O₅P
Molecular Weight:492.552
Hs Code.:

Synonyms:{3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester

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Chemical Property of {3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester

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Technology Process of {3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester

There total 8 articles about {3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 363622-67-7
3,5-bis(p-methoxystyryl)-1-bromomethylbenzene

: 122-52-1
triethyl phosphite

: 363622-69-9
{3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester

Guidance literature:: at 140 ℃; for 4h;
DOI:10.1021/jo015764r

Reference yield:

: 18226-42-1
1,3,5-Tris(bromomethyl)benzene

: 363622-69-9
{3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 33 percent / dimethylformamide / 3 h / 100 °C

2: 100 percent / 4 h / 140 °C

3: t-BuOK / tetrahydrofuran / 20 °C

4: aq. NaOH / 2 h / 20 °C

5: 79 percent / CBr₄; PPh₃ / acetonitrile / 20 °C

6: 100 percent / 4 h / 140 °C

With sodium hydroxide; carbon tetrabromide; potassium tert-butylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2: Arbuzov reaction / 3: Horner-Wadsworth-Emmons reaction / 6: Arbuzov reaction;
DOI:10.1021/jo015764r

Reference yield:

: 4464-18-0
1,3,5-tris(hydroxymethyl)benzene

: 363622-69-9
{3,5-Bis-[(E)-2-(4-methoxy-phenyl)-vinyl]-benzyl}-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / aq. HBr / acetic acid / 1 h / 20 °C

2: 33 percent / dimethylformamide / 3 h / 100 °C

3: 100 percent / 4 h / 140 °C

4: t-BuOK / tetrahydrofuran / 20 °C

5: aq. NaOH / 2 h / 20 °C

6: 79 percent / CBr₄; PPh₃ / acetonitrile / 20 °C

7: 100 percent / 4 h / 140 °C

With sodium hydroxide; carbon tetrabromide; potassium tert-butylate; hydrogen bromide; triphenylphosphine; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; acetonitrile; 3: Arbuzov reaction / 4: Horner-Wadsworth-Emmons reaction / 7: Arbuzov reaction;
DOI:10.1021/jo015764r