ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate

Base Information

Chemical Name:ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate
CAS No.:1421674-22-7
Molecular Formula:C₂₃H₁₉ClFN₃O₃S
Molecular Weight:471.94
Hs Code.:

Synonyms:ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate

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Chemical Property of ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate

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Technology Process of ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate

There total 3 articles about ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1421674-19-2
6-(2-chloro-6-ethoxypyridin-4-yl)-4-(4-fluorophenyl)-1,2-dihydro-2-thioxopyridine-3-carbonitrile

: 105-39-5
chloroacetic acid ethyl ester

: 1421674-22-7
ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate

Guidance literature:: 6-(2-chloro-6-ethoxypyridin-4-yl)-4-(4-fluorophenyl)-1,2-dihydro-2-thioxopyridine-3-carbonitrile; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

chloroacetic acid ethyl ester; In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.3390/molecules171113642

Reference yield:

: 1246465-18-8
1-(2-chloro-6-ethoxypyridin-4-yl)-3-(4-fluorophenyl)prop-2-en-1-one

: 1421674-22-7
ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate / ethanol / 5 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 2 h / 60 °C

With ammonium acetate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules171113642

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1421674-22-7
ethyl 2-(6-(2-chloro-6-ethoxypyridin-4-yl)-3-cyano-4-(4-fluorophenyl)pyridin-2-ylthio)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; N,N-diethylaniline / ethanol / 6 h / Reflux

2.1: ammonium acetate / ethanol / 5 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 2 h / 60 °C

With ammonium acetate; potassium carbonate; triethylamine; N,N-diethylaniline; In ethanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules171113642