(2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-pyroglutaMinol

Base Information

Chemical Name:(2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-pyroglutaMinol
CAS No.:910548-24-2
Molecular Formula:C₁₁H₁₉NO₄
Molecular Weight:229.276
Hs Code.:
Mol file:910548-24-2.mol

Synonyms:(4R,5S)-N-tert-butyloxycarbonyl-5-hydroxymethyl-4-methylpyrrolidin-2-one

Suppliers and Price of (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-pyroglutaMinol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,3R)-N-(tert-Butyloxycarbonyl)-3-methyl-pyroglutaminol
50mg
$ 1320.00

Medical Isotopes, Inc.
(2S,3R)-N-(tert-Butyloxycarbonyl)-3-methyl-pyroglutaminol
50 mg
$ 2200.00

Total 0 raw suppliers

Chemical Property of (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-pyroglutaMinol

Chemical Property:

Storage Temp.:Refrigerator
Solubility.:Ethyl Acetate

Purity/Quality:: (2S,3R)-N-(tert-Butyloxycarbonyl)-3-methyl-pyroglutaminol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2S,3R)-N-(tert-Butyloxycarbonyl)-3-methyl-pyroglutaminol is used in the preparation of (2S,3R)-3-Me glutamate residue of nonribosomal lipopeptides.

Technology Process of (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-pyroglutaMinol

There total 6 articles about (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-pyroglutaMinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 158135-16-1
(4R,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-4-methylpyrrolidin-2-one

: 910548-24-2
(4R,5S)-N-tert-butyloxycarbonyl-5-hydroxymethyl-4-methylpyrrolidin-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; acetic acid; at 0 - 20 ℃;
DOI:10.1021/ja062960c

Reference yield:

: 910548-23-1
(3R,4R,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-3,4-pyrazolinepyrrolidin-2-one

: 910548-24-2
(4R,5S)-N-tert-butyloxycarbonyl-5-hydroxymethyl-4-methylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / 3 h / 120 °C

2: 80 percent / H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C

3: 73 percent / TBAF / tetrahydrofuran; acetic acid; H₂O / 0 - 20 °C

With tetrabutyl ammonium fluoride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; water; acetic acid; ethyl acetate;
DOI:10.1021/ja062960c

Reference yield:

: 138871-58-6
(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 910548-24-2
(4R,5S)-N-tert-butyloxycarbonyl-5-hydroxymethyl-4-methylpyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 68 percent / diethyl ether / 72 h / 20 °C

2: 42 percent / 3 h / 120 °C

3: 80 percent / H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C

4: 73 percent / TBAF / tetrahydrofuran; acetic acid; H₂O / 0 - 20 °C

With tetrabutyl ammonium fluoride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; diethyl ether; water; acetic acid; ethyl acetate;
DOI:10.1021/ja062960c