(2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-5-oxo-pyrrolidinecarboxylic Acid

Base Information

Chemical Name:(2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-5-oxo-pyrrolidinecarboxylic Acid
CAS No.:910548-25-3
Molecular Formula:C₁₁H₁₇NO₅
Molecular Weight:243.26
Hs Code.:
Mol file:910548-25-3.mol

Synonyms:(2S,3R)-N-tert-butyloxycarbonyl-3-methylpyroglutamic acid

Suppliers and Price of (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-5-oxo-pyrrolidinecarboxylic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,3R)-N-(tert-Butyloxycarbonyl)-3-methyl-5-oxo-pyrrolidinecarboxylicAcid
25mg
$ 1320.00

Medical Isotopes, Inc.
(2S,3R)-N-(tert-Butyloxycarbonyl)-3-methyl-5-oxo-pyrrolidinecarboxylicAcid
2.5 mg
$ 650.00

Total 0 raw suppliers

Chemical Property of (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-5-oxo-pyrrolidinecarboxylic Acid

Chemical Property:

Storage Temp.:Refrigerator
Solubility.:Dichloromethane

Purity/Quality:: (2S,3R)-N-(tert-Butyloxycarbonyl)-3-methyl-5-oxo-pyrrolidinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-5-oxo-pyrrolidinecarboxylic Acid is used in the preparation of (2S,3R)-3-Me glutamate residue of nonribosomal lipopeptides.

Technology Process of (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-5-oxo-pyrrolidinecarboxylic Acid

There total 7 articles about (2S,3R)-N-(tert-Butyloxycarbonyl)-3-Methyl-5-oxo-pyrrolidinecarboxylic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 910548-24-2
(4R,5S)-N-tert-butyloxycarbonyl-5-hydroxymethyl-4-methylpyrrolidin-2-one

: 910548-25-3
(2S,3R)-N-tert-butyloxycarbonyl-3-methylpyroglutamic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 3h;
DOI:10.1021/ja062960c

Reference yield:

: 910548-23-1
(3R,4R,5S)-5-tert-butyldiphenylsilyloxymethyl-N-tert-butyloxycarbonyl-3,4-pyrazolinepyrrolidin-2-one

: 910548-25-3
(2S,3R)-N-tert-butyloxycarbonyl-3-methylpyroglutamic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 42 percent / 3 h / 120 °C

2: 80 percent / H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C

3: 73 percent / TBAF / tetrahydrofuran; acetic acid; H₂O / 0 - 20 °C

4: 70 percent / RuCl₃; NaIO₄ / acetonitrile; CCl₄; H₂O / 3 h / 20 °C

With ruthenium trichloride; sodium periodate; tetrabutyl ammonium fluoride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; tetrachloromethane; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1021/ja062960c

Reference yield:

: 138871-58-6
(S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

: 910548-25-3
(2S,3R)-N-tert-butyloxycarbonyl-3-methylpyroglutamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / diethyl ether / 72 h / 20 °C

2: 42 percent / 3 h / 120 °C

3: 80 percent / H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C

4: 73 percent / TBAF / tetrahydrofuran; acetic acid; H₂O / 0 - 20 °C

5: 70 percent / RuCl₃; NaIO₄ / acetonitrile; CCl₄; H₂O / 3 h / 20 °C

With ruthenium trichloride; sodium periodate; tetrabutyl ammonium fluoride; hydrogen; platinum(IV) oxide; In tetrahydrofuran; tetrachloromethane; diethyl ether; water; acetic acid; ethyl acetate; acetonitrile;
DOI:10.1021/ja062960c