Technology Process of 3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5 ethyl ester
There total 10 articles about 3-(4-(prop-1-yn-1-yl)phenyl)propionic acid-d5 ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; sodium chloride;
In
N,N-dimethyl-formamide;
for 48h;
Reflux;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 1H-imidazole / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere
2.1: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
6.1: sodium iodide / acetone / 1 h / 20 °C
7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Inert atmosphere
8.1: sodium chloride; water / N,N-dimethyl-formamide / 48 h / Reflux; Inert atmosphere
With
1H-imidazole; methanol; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; triethylamine; sodium iodide; sodium chloride;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate; methanol / 2 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C / Inert atmosphere
2.2: 0.5 h / 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5.1: sodium iodide / acetone / 1 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 0 - 20 °C / Inert atmosphere
7.1: sodium chloride; water / N,N-dimethyl-formamide / 48 h / Reflux; Inert atmosphere
With
methanol; n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hydride; potassium carbonate; triethylamine; sodium iodide; sodium chloride;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; mineral oil;