methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate

Base Information

Chemical Name:methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate
CAS No.:144225-91-2
Molecular Formula:C₄₄H₇₀N₂O₈
Molecular Weight:755.048
Hs Code.:

Synonyms:methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate

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Chemical Property of methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate

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Technology Process of methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate

There total 4 articles about methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2150-43-8
3,4-dihydroxybenzoic acid methyl ester

: 144225-89-8
(2R,4S)-2-(7-bromoheptyl)-2-methyl-3-acryloyl-4-tert-butyloxazolidine

: 144225-91-2
methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; acetone; for 15h; Heating;
DOI:10.1021/ja00101a049

Reference yield:

: 17696-11-6
8-bromooctanoic acid

: 144225-91-2
methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / tetrahydrofuran; diethyl ether / 1 h / -78 - 0 °C

2: 2.) MgSO₄, p-TsOH / 1.) 1 h, 2.) CH₂Cl₂, overnight

3: DMAP, 4-methylmorpholine / CH₂Cl₂ / 0 - 20 °C

4: 72 percent / K₂CO₃ / dimethylsulfoxide; acetone / 15 h / Heating

With 4-methyl-morpholine; dmap; magnesium sulfate; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/ja00101a049

Reference yield:

: 52330-02-6
9-bromononan-2-one

: 144225-91-2
methyl 3,4-bis(7-(2R-methyl-3-acryloyl-4S-tert-butyl-2-oxazolidinyl)heptyloxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) MgSO₄, p-TsOH / 1.) 1 h, 2.) CH₂Cl₂, overnight

2: DMAP, 4-methylmorpholine / CH₂Cl₂ / 0 - 20 °C

3: 72 percent / K₂CO₃ / dimethylsulfoxide; acetone / 15 h / Heating

With 4-methyl-morpholine; dmap; magnesium sulfate; potassium carbonate; toluene-4-sulfonic acid; In dichloromethane; dimethyl sulfoxide; acetone;
DOI:10.1021/ja00101a049